The two teams have met eight times in the European Cup, with Real winning four times and Liverpool three.
Real Madrid beat Barcelona 4-2 to cut their arch-rivals' lead at the top of the Spanish League to six points with seven matches to play.
City completed the treble of Champions League, Premier League and FA Cup titles, matching Manchester United's feat in 1999 and drawing comparisons with Guardiola's 2008-09 Barcelona team.
A round-up of the weekend's action from Europe's leading leagues.
France's golden age of soccer is over, perhaps not for good but certainly for now.
England's midfielder expressed disappointment over the back pass which led to France's match-winning penalty.
The Belgian forward came off the bench to make his Real debut in Saturday's 3-2 win over Levante, having had his start to life at the club hit by a thigh injury the day before the La Liga season began.
The result keeps Real Madrid in third spot in the Spanish first division standings, a point behind Valencia and five adrift of leaders Real Sociedad.
He finished ahead of Oliver Kahn and Zinedine Zidane in the voting by national team coaches.
Real Madrid face Liverpool in the Champions League final in Kiev. Below are five key tactical factors that could affect the outcome of Saturday's match.
News of all that's transpired on and off the football field
Real Madrid star striker Cristiano Ronaldo will travel with the team for the first leg of the Champions League semi-final clash against Manchester City after recovering from a thigh injury.
'I'm not asking them to name streets after me, the only thing I ask is that they don't boo me here'
Gareth Bale will undergo ankle surgery next week to repair damaged tendons, Real Madrid said on Thursday. The Wales international picked up the injury during Tuesday's 2-1 Champions League victory at Sporting Lisbon. "Real Madrid Sanitas Medical Services have decided that Gareth Bale will undergo an operation following the traumatic dislocation of the peroneal tendons of his right ankle," La Liga leaders Real said in a statement.
Here, Reuters Sport highlights five reasons why last season's double winners have collapsed.
Cristiano Ronaldo achieved another milestone in his Real Madrid career when he scored his 200th goal at the Bernabeu on Sunday but he looks like failing in his bid to become La Liga's top scorer for the third season in a row.
'To all of these heroic people: football thanks you, football remembers you and football supports you'
Karim Benzema netted a second-half hat-trick as Real Madrid got back to winning ways with a 3-0 victory over Athletic Bilbao in La Liga on Sunday.
Barcelona finished three points behind Real Madrid last season but there is concern the gap between Spain's biggest two sides could be far larger this season.
Meanwhile, Real Mallorca made a dream return to La Liga with a 2-1 victory over Eibar at the Estadi Son Moix on Saturday, less than two months after sealing back-to-back promotions to rejoin Spain's soccer elite.
Cristiano Ronaldo missed a penalty as Real Madrid and neighbours Atletico were held to draws leaving Barcelona with an eight-point lead at the top of La Liga and 13 matches left.
Real Madrid winger Gareth Bale has expressed disappointment over the sacking of Rafael Benitez as a manager, saying that it was really sad to see him go. "I had a very good relationship with Rafa, obviously it was a big disappointment to see him go," Bale was quoted as saying by goal.com. Benitez was replaced by former French great Zinedine Zidane after just seven months in charge due to club's recent slump in form in the La Liga. Zidane's appointment seemed to be in favour of Real as they thrashed Deportivo La Coruna 5-0 in La Liga match.
Real Madrid returned to the top of La Liga after winning a testing game at Osasuna 3-1 on Saturday.
Valencia forward Carlos Soler scored a hat-trick of penalties as his side beat La Liga champions Real Madrid 4-1 at home in an extraordinary match on Sunday.
Barcelona beat local rivals Espanyol 2-0 in the Catalan derby on Saturday to maintain their 10 point lead at the top of La Liga, while Real Madrid scraped a 3-2 win against bottom side Huesca on Sunday.
Manager Mauricio Pochettino has reiterated his happiness at Tottenham Hotspur in some of his first public comments after he emerged as a leading candidate to replace Zinedine Zidane at Real Madrid.
European champions Real Madrid head to rampaging Borussia Dortmund for their Champions League Group F game on Tuesday in a frazzled state with their buoyant start to the season having been punctured by successive La Liga draws.
Nadal, a Real fan despite his uncle Miguel Angel making over 200 appearances for arch-rivals Barcelona, was seen speaking to umpire Mohamed Lahyani about his team's 0-0 home draw with Real Betis on Saturday and was less than impressed with what he saw.
Former Barcelona coach Pep Guardiola said bitter rivals Real Madrid were a 'spectacular' side after they won a record 13th European title in Kiev on Saturday.
Photos from the Champions League match played between Real Madrid and AS Roma at the Stadio Olimpico on Wednesday
Hazard is set to be fit for the 'Clasico' against Liga leaders Barcelona
Real Madrid's 5-0 thrashing of Granada on Saturday equalled a Spanish record of 39 games unbeaten in all competitions. Reuters Sport takes a look at the factors behind their run.
A true legend of the game who paved the way and taught so many of us how to be as a player and as a person.
Real are unbeaten since February, winning 10 of their last 12 games. In contrast, Barcelona have won just two of their previous five in all competitions and were dumped out of Europe in midweek.
Used to relying heavily on one key player for their European glory in the past -- Michel Platini and Zinedine Zidane in the 1984 and 2000 tournaments respectively -- French fans have two talented players on whom to pin their hopes at Euro 2016.